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One-Pot, Regioselective Synthesis of Substituted Arylglycines for Kinetic Resolution by Penicillin G Acylase

โœ Scribed by Peter Grundmann; Wolf-Dieter Fessner


Book ID
101421265
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
247 KB
Volume
350
Category
Article
ISSN
1615-4150

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A new chemoenzymatic synthesis of Cefazolin through the correct assembly of three bioU'ansformations catalysed by D-aminoacid oxidase, glutaryl acylase and penicillin G acylase is described. This multienzymatic synthesis has been performed from the natural Cephalosporin C in fully aqueous medium wit