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One-Pot Organocatalytic Domino Michael-Aldol and Intramolecular S N 2 Reactions. Asymmetric Synthesis of Highly Functionalized Epoxycyclohexanone Derivatives

✍ Scribed by Marigo, Mauro; Bertelsen, Søren; Landa, Aitor; Jørgensen, Karl Anker


Book ID
125931246
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
113 KB
Volume
128
Category
Article
ISSN
0002-7863

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A Highly Enantioselective Catalytic Domi
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## Abstract The highly enantioselective organocatalytic domino aza‐Michael/aldol reaction is presented. The unprecedented, chiral amine‐catalyzed asymmetric domino reactions between 2‐aminobenzaldehydes and α,β‐unsaturated aldehydes proceed with excellent chemo‐ and enantioselectivity to give the c