One-pot green procedure for Biginelli reaction catalyzed by novel task-specific room-temperature ionic liquids
✍ Scribed by Fang Dong; Luo Jun; Zhou Xinli; Ye Zhiwen; Liu Zuliang
- Book ID
- 103834739
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 181 KB
- Volume
- 274
- Category
- Article
- ISSN
- 1381-1169
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✦ Synopsis
Cheap and reusable task-specific ionic liquids that bear an alkanesulfonic acid group in an acyclic trialkylammonium cation were found to be effective catalysts for synthesizing 3,4-dihydropyrimidine-2-(1H)-ones via the one-pot three-component Biginelli reaction. The satisfactory results were obtained with good yields, short reaction time and simplicity in the experimental procedure. The catalysts could be recycled and reused six times without noticeably decrease in the catalytic activity.
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## Abstract A novel __Biginelli__‐like cyclocondensation reaction is efficiently catalyzed by iodotrimethylsilane (Me~3~SiI) in MeCN. The reaction proceeds at room temperature by a three‐component one‐pot condensation of ketones with aldehydes and urea to afford 5‐unsubstituted 3,4‐dihydropyrimidin