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One-pot four-component synthesis of highly substituted pyrroles in gluconic acid aqueous solution

✍ Scribed by Li, Bao-Le; Li, Pei-He; Fang, Xue-Na; Li, Chun-Xiao; Sun, Jing-Lei; Mo, Li-Ping; Zhang, Zhan-Hui

Book ID
120527440
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
522 KB
Volume
69
Category
Article
ISSN
0040-4020

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## Abstract An efficient environmentally friendly synthesis of poly‐substituted pyrimidines has been developed via a four‐component, one‐pot reaction of malononitrile, carbon disulfide, alkyl halide and __S__‐alkylisothiouronium salt in water at room temperature. Water as solvent, mild reaction con