An Efficient Four-Component, One-Pot Synthesis of Poly-Substituted Pyrimidines in Water

✍ Scribed by Zhongqing WANG; Zemei GE; Tieming CHENG; Runtao LI

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 75 KB
• Volume: 27
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200990139

✦ Synopsis

Abstract

An efficient environmentally friendly synthesis of poly‐substituted pyrimidines has been developed via a four‐component, one‐pot reaction of malononitrile, carbon disulfide, alkyl halide and S‐alkylisothiouronium salt in water at room temperature. Water as solvent, mild reaction conditions, short reaction time, simple experimental procedures, broad scope of substrates and good yields are the main advantages of this method.