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One-pot efficient synthesis ofNα-urethane-protected β- and γ-amino acids

✍ Scribed by Marta Cal, Mariusz Jaremko, Łukasz Jaremko, Piotr Stefanowicz


Book ID
120920555
Publisher
Springer
Year
2012
Tongue
English
Weight
353 KB
Volume
44
Category
Article
ISSN
0939-4451

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Synthesis of N-urethane protected α-alky
✍ Marielle Paris; Jean-Alain Fehrentz; Annie Heitz; Jean Martinez 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 214 KB

N-protected cx-alkyl--t-amino-13-keto-esters were synthesized from the corre,q~nding Nurethane prolected N-carboxyanhydride (UNCAs) by reaction with lithium enolates in fairly good yields. These compounds are candidates for mimicking the transition state analogue in enzyme inhibitors. They constitut