## Abstract An effective route to hydantoins is described, based on the 2β:β1β:β1 addition of arylsulfonyl isocyanates, dialkyl acetylenedicarboxylates, and dialkyl trialkylsilyl phosphites. The resulting tetrasubstituted, stable hydantoins **4**/**4β²** (__Table__) were obtained in excellent yields
β¦ LIBER β¦
One-Pot Diastereoselective Synthesis of New Racemic and Achiral Spirohydantoins.
β Scribed by Nosrat O. Mahmoodi; Ziba Khodaee
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 18 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A simple and fast threeβcomponent diastereoselective synthesis of biologically important spiro scaffold **4** was carried out in reasonable purity starting from readily available 1__H__βindoleβ2,3βdione **1**, ethyl cyanoacetate **2** and 4βhydroxycoumarin **3** under microwave in high