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One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction

✍ Scribed by Gary Gellerman; Vladimir Gaisin; Tamara Brider

Book ID
104097226
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
476 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and S N Ar reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: One-Pot Derivatizat
ChemInform Abstract: One-Pot Derivatization of Medicinally Important 9-Aminoacridines by Reductive Amination and SNAr Reaction.
✍ Gary Gellerman; Vladimir Gaisin; Tamara Brider πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 2 views

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Highly chemoselective reductive aminatio
Highly chemoselective reductive amination-coupling by one-pot reaction of aldehydes, HMDS and NaBH4
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An efficient and highly chemoselective synthesis of symmetrical secondary amines via reductive amination of aldehydes with inexpensive and commercially available HMDS and sodium borohydride in high to quantitative yields is reported.