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One-Pot Asymmetric Synthesis of β-Cyanohydroxymethyl α-Amino Acid Derivatives: Formation of Three Contiguous Stereogenic Centers.

✍ Scribed by Shin-ichi Watanabe; Armando Cordova; Fujie Tanaka; Carlos F. III Barbas


Publisher
John Wiley and Sons
Year
2003
Weight
176 KB
Volume
34
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Asymmetric Mannich
✍ H. KUNZ; A. BURGARD; D. SCHANZENBACH 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

Asymmetric Mannich Synthesis of β-Amino Acids with Two New Stereogenic Centers at the α and β Positions. -The ZnCl2-catalyzed Mannich reaction of N-galactosyl aldimines, e.g. ( I), with ketene acetals as the C-nucleophiles furnishes β-amino acid derivatives, important building blocks of natural prod