We have identified three unrelated individuals and three members of a family with the non-deletion form of A ␥-hereditary persistence of fetal hemoglobin (HPFH). Molecular analysis showed that each individual is a heterozygote for a previously described -195 A ␥ (C→G) mutation. The -globin gene clu
One haplotype is associated with the Swiss type of hereditary persistence of fetal hemoglobin in the Yugoslavian population
✍ Scribed by G. D. Efremov; I. Gjorgovski; N. Stojanovski; J. C. Diaz-Chico; T. Harano; F. Kutlar; T. H. J. Huisman
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 500 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0340-6717
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Restriction endonuclease analyses of DNA from one Black G gamma A gamma-HPFH homozygote and four Black and one Indian G gamma A gamma-HPFH heterozygotes have identified three different HPFH types which are the result of large deletions including the delta and beta genes. Two of the types are compara
We report a study of four families of Italian origin in which heterocellular HPFH is inherited linked to beta thalassemia over two or three generations. The HPFH + beta thalassemia carriers showed thalassemic blood pictures and elevated HbF and F-cell number without increase in the HbF/F-cell conten