Restriction endonuclease analyses of DNA from one Black G gamma A gamma-HPFH homozygote and four Black and one Indian G gamma A gamma-HPFH heterozygotes have identified three different HPFH types which are the result of large deletions including the delta and beta genes. Two of the types are compara
✦ LIBER ✦
Differences between the levels ofGγ chain in the fetal hemoglobin in two types of hereditary persistence of fetal hemoglobin are linked with a variation in the DNA sequence
✍ Scribed by I. Bakioglu; A. Kutlar; T. H. J. Huisman
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 165 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0006-2928
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We report a study of four families of Italian origin in which heterocellular HPFH is inherited linked to beta thalassemia over two or three generations. The HPFH + beta thalassemia carriers showed thalassemic blood pictures and elevated HbF and F-cell number without increase in the HbF/F-cell conten