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Oncostatin M induces functional and structural impairment of blood–brain barriers comprised of rat brain capillary endothelial cells

✍ Scribed by Fuyuko Takata; Noriko Sumi; Tsuyoshi Nishioku; Eriko Harada; Tomoya Wakigawa; Hideki Shuto; Atsushi Yamauchi; Yasufumi Kataoka


Book ID
116770585
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
760 KB
Volume
441
Category
Article
ISSN
0304-3940

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## Abstract Claudins are thought to be major components of tight junctions (TJs), and claudin‐5 and ‐12 are localized at TJs of the blood‐brain barrier (BBB). Claudin‐5‐deficient mice exhibit size‐selective (<800 Da) opening of the BBB. The purpose of this study was to clarify the expression levels