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Oncogenicity Testing of 2-Ethylhexanol in Fischer 344 Rats and B6C3F1 Mice

โœ Scribed by B.D. Astill; R. Gingell; D. Guest; J. Hellwig; J.R. Hodgson; K. Kuettler; W. Mellert; S.R. Murphy; R.L. Sielken Jr.; T.R. Tyler

Book ID
115608623
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
170 KB
Volume
31
Category
Article
ISSN
0272-0590

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โœ Richard D. Irwin; Scot L. Eustis; Steven Stefanski; Joseph K. Haseman ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 740 KB

Glycidol, a simple aliphatic epoxide, was administered by gavage in water to groups of male and female F344/N rats and B6C3F1 mice. Rats received 0, 37.5 or 75 mg kg-' and mice received 0, 25 or 50 mg kg-' daily, 5 days per week for 2 years. Exposure to glycidol was associated with dose-related incr