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Oncogenicity evaluation of resveratrol in p53(±) (p53 knockout) mice

✍ Scribed by T.L. Horn; M.J. Cwik; R.L. Morrissey; I. Kapetanovic; J.A. Crowell; T.D. Booth; D.L. McCormick


Book ID
116461707
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
190 KB
Volume
45
Category
Article
ISSN
0278-6915

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Nullizygous p53 knockout (p53 À/À ) mice are highly susceptible to spontaneous tumorigenesis, in particular malignant lymphomas at an early age. Heterozygous p53 knockout (p53 /À ) mice develop spontaneous tumors less frequently but may show increased susceptibility to chemical carcinogens. In this