Mapping of genetic modifiers of thymic lymphoma development in p53-knockout mice
β Scribed by Ochiai, Yukie; Tamura, Yasushi; Saito, Yuko; Matsuki, Atsushi; Wakabayashi, Yu-ichi; Aizawa, Yoshifusa; Niwa, Ohtsura; Kominami, Ryo
- Book ID
- 110067323
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 146 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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Nullizygous p53 knockout (p53 Γ/Γ ) mice are highly susceptible to spontaneous tumorigenesis, in particular malignant lymphomas at an early age. Heterozygous p53 knockout (p53 /Γ ) mice develop spontaneous tumors less frequently but may show increased susceptibility to chemical carcinogens. In this