Immune reactivity prior to development of thymic lymphoma in C57BL mice

✍ Scribed by Ruth G. Doell; Christiane De Vaux; St. Cyr; Pierre Grabar

• Book ID: 102273992
• Publisher: John Wiley and Sons
• Year: 1967
• Tongue: French
• Weight: 492 KB
• Volume: 2
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910020205

✦ Synopsis

The immune response of C57BL mice was tested following treatment with either irradiation or methylcholan€h~ene. Response to a weak histocompatibility antigen difference (male to female skin grafts) was found to be depressed after both treatments as was the response to a strong ( H 2 ) antigen difference as measured by the Simonsen graft-versus-host reaction.

The potent immunodepressant drug 6-mercaptopurine was found to be carcinogenic in this strain of mouse, inducing approximately 29 % thymic lymphomas when given to young mice. Females of the high spontaneous lymphoma strain A K R were found to have a markedly decreased ability to reject male skin grafls as compared with the CS7BL strain.