## Abstract The limitation of proliferative potential in human somatic cells imposed by replicative senescence has been proposed as a mechanism of tumor suppression. The E3 ubiquitin ligase Smurf2 is upβregulated during replicative senescence in response to telomere shortening, and induces senescen
Oncogene-Induced Senescence and its Role in Tumor Suppression
β Scribed by Jay P. Reddy; Yi Li
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 313 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1083-3021
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