On the way to unsymmetrical terpyridines carrying carboxylic acids
β Scribed by Jean-Christophe Raboin; Gilbert Kirsch; Marc Beley
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2000
- Tongue
- English
- Weight
- 251 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-152X
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β¦ Synopsis
Abstract
For the first time arv unsymmetrical 2,2β²β6β²2β³βterpyridine carry two carboxylic acids has been prepared using Hantzsch's method for pyridine ring formation and furan as a latent carboxylic group.
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The transformation of acids into aldehydes in a one-pot process is performed through the thermal decomposition of pentacoordinated silicon species.
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Quantum similarity measures were used to estimate dissociation constants for acid-base equilibria. It is proposed that the dissociation constant of a carboxylic acid may be described by the electronic density function of the COOH group and quantified by the self-similarity measure of this fragment.