𝔖 Bobbio Scriptorium
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On the substrate specificity of the bacterial ɛ-lysine acylase

✍ Scribed by Ichiro Chibata; Tetsuya Tosa; Tsutomu Ishikawa

Book ID
119404425
Publisher
Elsevier Science
Year
1964
Tongue
English
Weight
436 KB
Volume
104
Category
Article
ISSN
0003-9861

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beta-Lactam acylases are crucial for the synthesis of semisynthetic cephalosporins and penicillins. Unfortunately, there are no cephalosporin acylases known that can efficiently hydrolyse the amino-adipic side chain of Cephalosporin C. In a previous directed evolution experiment, residue Asn266 of t