Structure dependence in the solvolysis k
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John Haseltine; Jason W. Runyon
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Article
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2010
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Elsevier Science
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French
β 190 KB
To better understand acyl transfer reactions of oligopeptides, seventeen N-acyl amino acid esters were solvolyzed in mildly basic methanol-d 4 . All show pseudo-first-order kinetics by 1 H NMR. The rate constant varies up to 400-fold with the identity of the amino acid and up to 6200-fold with the i