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On the stability of 2-aminoselenophene-3-carboxylates: potential dual-acting selenium-containing allosteric enhancers of A1 adenosine receptor binding

✍ Scribed by Aumann, Kylee M.; Scammells, Peter J.; White, Jonathan M.; Schiesser, Carl H.


Book ID
118206222
Publisher
Royal Society of Chemistry
Year
2007
Tongue
English
Weight
352 KB
Volume
5
Category
Article
ISSN
1477-0520

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A Sonogashira coupling strategy was employed to synthesize a new series of allosteric modulators for the A1 adenosine receptor based on the 2-amino-3-(p-chlorobenzoyl)-4-substituted thiophene skeleton, with a two-carbon (rigid or flexible) linker between the 5-position of the thiophene ring and a (h