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On the source of “Minor thymine” in DNA from a Novikoff rat hepatoma cell line

✍ Scribed by Thomas W. Sneider

Book ID
118917359
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
282 KB
Volume
79
Category
Article
ISSN
0022-2836

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A mutation in subunit B of the DNA polymerase α–primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase α–primase complex
✍ Odilia Popanda; Claudia Flohr; Jia-Chun Dai; Andreas Hunzicker; Heinz Walter Thi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

Mutated constituents of the DNA replication complex might contribute to the mutational load of the genome during tumor development by impairing DNA synthesis as well as cell cycle-related control of DNA replication. To prove or disprove this hypothesis, we looked for mutations in the cDNA sequences