A mutation detected in DNA polymerase δ cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme

A mutation in subunit B of the DNA polym

A mutation in subunit B of the DNA polymerase α–primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase α–primase complex

✍ Odilia Popanda; Claudia Flohr; Jia-Chun Dai; Andreas Hunzicker; Heinz Walter Thi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

Mutated constituents of the DNA replication complex might contribute to the mutational load of the genome during tumor development by impairing DNA synthesis as well as cell cycle-related control of DNA replication. To prove or disprove this hypothesis, we looked for mutations in the cDNA sequences