Effect of PEGylation on the solution con
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Yanling Lu; Stephen E. Harding; Alison Turner; Bryan Smith; Diljeet S. Athwal; J
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Article
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2008
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John Wiley and Sons
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English
β 528 KB
Covalent attachment of poly(ethylene glycol) (PEG) to therapeutic antibody fragments has been found effective in prolonging the half-life of the protein molecule in vivo. In this study analytical ultracentrifugation (AUC) in combination with small angle X-ray scattering (SAXS) has been applied to a