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On the role of additive hormone monotherapy with tamoxifen, medroxyprogesterone acetate and aminoglutethimide, in advanced breast cancer

✍ Scribed by Petru, E. ;Schmähl, D.


Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
929 KB
Volume
65
Category
Article
ISSN
1432-1440

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Human breast cancer cells (MCF-7) showed increased responses to methotrexate and vincristine after a 48-hr pretreatment with medroxyprogesterone acetate. The effect of the hormone, which was detectable at concentrations of between 10 and IOOnM, was independent of its growth-inhibitory action. These