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On the road to cancer: aneuploidy and the mitotic checkpoint

✍ Scribed by Kops, Geert J. P. L.; Weaver, Beth A. A.; Cleveland, Don W.

Book ID: 109947475
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 546 KB
Volume: 5
Category: Article
ISSN: 1474-1776
DOI: 10.1038/nrc1714

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## Abstract Aneuploidy and genetic instability are a hallmark of colorectal cancer and other solid tumors, and they are thought to enhance tumor progression. The gene __MAD2L____2__ (mitotic arrest deficient 2‐like 2) encodes the spindle checkpoint protein MAD2L2 (or MAD2B), a key component of a su