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Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

โœ Scribed by Takahashi, Takao; Haruki, Nobuhiro; Nomoto, Shuji; Masuda, Akira; Saji, Shigetoyo; Osada, Hirotaka; Takahashi, Takashi


Book ID
110062224
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
193 KB
Volume
18
Category
Article
ISSN
0950-9232

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Mutations in mitotic checkpoint genes have been detected in several human cancers, and these cancers exhibit chromosomal instability. Aneuploid stem cells seem to result from chromosomal instability and have been reported in many lung cancers. To determine whether alteration of mitotic checkpoint re