Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer

Somatic mutation of the hBUB1 mitotic ch

Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer

✍ Akihiko Gemma; Masahiro Seike; Yoko Seike; Kazutsugu Uematsu; Suguru Hibino; Fut 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 1 views

Mutations in mitotic checkpoint genes have been detected in several human cancers, and these cancers exhibit chromosomal instability. Aneuploid stem cells seem to result from chromosomal instability and have been reported in many lung cancers. To determine whether alteration of mitotic checkpoint re