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On the prevalence of the PAX8-PPARG fusion resulting from the chromosomal translocation t(2;3)(q13;p25) in adenomas of the thyroid

✍ Scribed by Markus Klemke; Norbert Drieschner; Anne Laabs; Volkhard Rippe; Gazanfer Belge; Jörn Bullerdiek; Wolfgang Sendt


Book ID
116332592
Publisher
Elsevier
Year
2011
Tongue
English
Weight
490 KB
Volume
204
Category
Article
ISSN
2210-7762

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A subgroup of pleomorphic adenomas of the salivary glands is characterized by translocations involving chromosome 8, with consistent breakpoints at 8q 12. As part of a positional cloning effort to isolate the gene(s) affected by these translocations we now report the mapping of the 8q I 2 breakpoint