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On the pathogenesis of anticonvulsant-drug-induced alterations of calcium metabolism

✍ Scribed by K. Kruse

Publisher
Springer
Year
1982
Tongue
English
Weight
456 KB
Volume
138
Category
Article
ISSN
0340-6997

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The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s