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Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA

✍ Scribed by Arie Goldlust; Ti-Zhi Su; Devin F. Welty; Charles P. Taylor; Dale L. Oxender

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
683 KB
Volume
22
Category
Article
ISSN
0920-1211

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## Abstract To probe the effect of glutamine and GABA on metabolism of [U‐^13^C]glutamate, cerebellar astrocytes were incubated with [U‐^13^C]glutamate (0.5 mM) in the presence and absence of glutamine (2.5 mM) or GABA (0.2 mM). It could be shown that consumption of [U‐^13^C]glutamate was decreased