✍ Scribed by D. Palm; H. Grobecker
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Sixteen rats of both sexes of a strain selectively bred for high performance levels in an aversive learning task, were examined for differences in rearing frequency and escape/avoidance performance under various doses of the drugs reserpine and prenylamine. At the highest dosages employed 4.0 mg/kg
The action of 20 mg/kg, i.p. of the drug prenylamine (Segontin) upon two forms of exploratory activity was examined in strains of rats selectively bred for differences in emotionality. The drug significantly depressed ambulation in an Open Field arena compared to placebo and although not apparently
Following oral administration of DL-[14C]prenylamine, about 40% of the dose administered was excreted in urine within 10 days. Less than 0.1% of the dose was excreted as unchanged prenylamine. The drug was extensively metabolized to at least 20 to 25 metabolites. The structure of 12 metabolites coul