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The action of the drug prenylamine (Segontin) on exploratory activity and aversive learning in a selected strain of rats

✍ Scribed by Keir Gregory

Publisher: Springer
Year: 1968
Tongue: English
Weight: 379 KB
Volume: 13
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00401615

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✦ Synopsis

Sixteen rats of both sexes of a strain selectively bred for high performance levels in an aversive learning task, were examined for differences in rearing frequency and escape/avoidance performance under various doses of the drugs reserpine and prenylamine. At the highest dosages employed 4.0 mg/kg of reserpine and 40.0 mg/kg of prenylamine, activity and conditioned ~voidance performance was depressed. These findings seem to suggest that the depletion of the catecholamine levels of the organism may be responsible for th~se effects and that disruption of aversive learning is due to the action of the drugs in depressing activity, rather than some more direct action on the learning process itself.

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