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On the Mechanism by Which Saxitoxin Binds to and Blocks Sodium Channels

✍ Scribed by GARY STRICHARTZ; THOMAS RANDO; SHERWOOD HALL; JANE GITSCHIER; LINDA HALL; BARBARAJEAN MAGNANI; CHRISTINA HANSEN BAY

Book ID
118723121
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
858 KB
Volume
479
Category
Article
ISSN
0890-6564

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✍ G. Hansen; W. Ulbricht πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 826 KB

Voltage clamp experiments were done on single myelinated frog nerve fibres. The rate of block of Na + channels by tetrodotoxin (TTX) was obtained from changes in peak Na + current during 1-Hz trains of depolarizing impulses. In hypertonic Na+-rich solution (216 raM) the stationary block was reduced