On the Ionization State of the Substrate in the Active Site of Glutamate Racemase. A QM/MM Study about the Importance of Being Zwitterionic †

Role of each residue in catalysis in the

Role of each residue in catalysis in the active site of pyrimidine nucleoside phosphorylase from Bacillus subtilis: A hybrid QM/MM study

✍ Xue-Feng Gao; Xu-Ri Huang; Chia-Chung Sun 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 439 KB

Computational mutagenesis reveals the ro

Computational mutagenesis reveals the role of active-site tyrosine in stabilising a boat conformation for the substrate: QM/MM molecular dynamics studies of wild-type and mutant xylanases

✍ Soliman, Mahmoud E. S. ;Ruggiero, Giuseppe D. ;Pernía, J. Javier Ruiz ;Greig, Ia 📂 Article 📅 2009 🏛 Royal Society of Chemistry 🌐 English ⚖ 848 KB

1H NMR T1 relaxation rate study on subst

1H NMR T1 relaxation rate study on substrate orientation of fluoromethylanilines in the active sites of microsomal and purified cytochromes P450 1A1 and 2B1

✍ Janneke Koerts; Ivonne M.C.M. Rietjens; Marelle G. Boersma; Jacques Vervoort 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 519 KB

Bio-Assays for Oxidative Stress Status |

Bio-Assays for Oxidative Stress Status || IN VIVO TOTAL ANTIOXIDANT CAPACITY: COMPARISON OF DIFFERENT ANALYTICAL METHODS11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the U.S. Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.Address correspondence to: R. L. Prior, Ph.D., USDA, ARS, HNRCA, 711 Washington St., Boston, MA 02111, USA; Tel: (617) 556–3311; Fax: (617) 556-3222; E-Mail: [email protected]. Ronald Prior is a Nutritionist and Laboratory Chief of the Phytochemical Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University, Boston, MA. Dr. Prior received his B.S. degree with honors from the University of Nebraska and he received his Ph.D. in Nutrition and Biochemistry from Cornell University in 1972. Dr. Prior has worked with the USDA for more than 20 years.During the past 12 years at the HNRCA, he has been Scientific Program Officer and has directed research activities dealing with the role of flavonoid and other phenolic food components on antioxidant status, their metabolism, and relationships to diseases of aging.Guohua Cao, M.D., Ph.D., is currently a Scientist II at HNRCA. Dr. Cao studied medicine in Nantong Medical College in 1979 and at Nanjing Medical University in 1984. He obtained his Ph.D. in nutritional biochemistry from Beijing Medical University in 1990. Dr. Cao came to the United States in 1991 and worked at NIH where he was instrumental in developing the ORAC method.

✍ PRIOR, RONALD L. 📂 Article 📅 2001 🏛 Elsevier 🌐 English ⚖ 986 KB

This work contains over thirty chapters by leading researchers in the field of oxidative biology, originally presented as articles in an extended Forum in the highly-cited journal, *Free Radical Biology & Medicine*. The papers in this Forum (or Symposium-in-print) spanned seven issues of the journal