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On the interaction of 5-hydroxytryptophan and 5-hydroxytryptamine with dopamine metabolism in the rat striatum

✍ Scribed by N. Awazi; H. C. Guldberg

Book ID
112340745
Publisher
Springer-Verlag
Year
1978
Tongue
English
Weight
894 KB
Volume
303
Category
Article
ISSN
0028-1298

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The kynurenine pathway metabolites kynurenine, 3-hydroxykynurenine and xanthurenic acid have been tested against 5-hydroxytryptamine (5-HT) and 5-hydroxytryptophan (5-HTP)-induced head twitches in the mouse in a dose-range of 0.5-5.0 mg/ kg. Kynurenine and 3-hydroxykynurenine were highly active. Low