On the estimation of hypoxic ventilatory response

✍ Scribed by Richard M. Engeman; Duane L. Sherrill; George D. Swanson

• Book ID: 103053939
• Publisher: Elsevier Science
• Year: 1985
• Tongue: English
• Weight: 549 KB
• Volume: 18
• Category: Article
• ISSN: 0010-4809
• DOI: 10.1016/0010-4809(85)90030-8

✦ Synopsis

The shape parameter, A, has been used to assess hypoxic sensitivity (ventilatory response, VE, to lowered alveolar oxygen tension, PAO2) in the model of the form VE = VEO + A/(PAO2 - C) where C is held constant at 32. In this paper we examine the consequence of holding C constant versus estimating both A and C from the data. Using computer-simulated data from 59 subjects whose A and C values had been previously determined, we indicate that when the actual C value is substantially different from 32, the model with C = 32 does not fit the data. In this case, the estimated A value with C = 32 is highly dependent upon the lowest value of PAO2 obtained in the experimental protocol and can be markedly different from the actual A value. In contrast, when C is also estimated from the subject's data the model fits the data and the estimate of A is unbiased but the precision may be diminished when the actual value of C is low. To improve this precision, we propose a Bayesian estimation scheme that adds a "soft" constraint on C.