๐”– Bobbio Scriptorium
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On the combination of photodynamic therapy with ionizing radiation

โœ Scribed by Zivile Luksiene; Audrone Kalvelyte; Rosanna Supino

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
204 KB
Volume
52
Category
Article
ISSN
1011-1344

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โœฆ Synopsis

Ehrlich ascites carcinoma growth and cell damage have been examined after photodynamic therapy (PDT), radiotherapy (RT) and combined treatment. Haematoporphyrin dimethyl ether (HPde) is used as a photosensitizer for PDT and tested as a radiosensitizer for RT. For PDT a non-coherent light source (370-l-680 nm) equipped with filters is used. g-Irradiation consists of 60 Co irradiation at a dose of 2 Gy. Both PDT and RT induce a significant delay and inhibition in tumour growth (33 and 38%, respectively). Nevertheless cell damage after these treatments is different: after PDT the cell membrane integrity is damaged and no serious chromosomal aberrations are observed; whereas after g-irradiation there is no cell membrane integrity damage, but more significant DNA injuries are observed. It seems evident that HPde is able to act as a photosensitizer as well as a radiosensitizer. Combining PDT and RT produces an additive effect, not dependent on the sequence in which the two treatments are given, when a 1 h time window is used.

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