✦ LIBER ✦

Glucose administration combined with photodynamic therapy of cancer improves therapeutic efficacy

✍ Scribed by J. Stuart Nelson; Sol Kimel; Lisa Brown; Michael W. Berns

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 533 KB
Volume: 12
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.1900120207

No coin nor oath required. For personal study only.

✦ Synopsis

Both the scope and the levels of activity in basic research and in the clinical applications of PDT, have grown enormously during the past few years. Several studies have examined the synergism of hyperthermia and chemotherapeutic agents in combination with PDT to enhance tumor eradication. The present study investigates the synergism of glucose administration combined with phototherapy.

The results of this study suggest that glucose administration is simple and well tolerated, and combined with PDT produces a larger percentage of animals cured than using PDT alone. Furthermore, the results indicate that this approach requires lower amounts of light and might enable dosage reduction of photosensitizer for optimal response, with minimal side effects, to the treatment of cancer.

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