On the binding of Mg2+, Ca2+, Zn2+ and Cu+ metal cations to 2 ′ -deoxyguanosine: Changes on sugar puckering and strength of the -glycosidic bond
✍ Scribed by M.S. Ahmadi; A. Fattahi
- Book ID
- 113890258
- Publisher
- Elsevier
- Year
- 2011
- Tongue
- English
- Weight
- 762 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1026-3098
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The interaction of Mg2+, Ca2+, Zn2+, and Cd2' with calf thymus DNA has been investigated by Raman spectroscopy. These spectra reveal that all of these ions, and particularly Zn2+, bind to phosphate groups of DNA, causing a slight structural change in the polynucleotide at very small metal : D N A (
lnnsbruck lnnrain 5La A-6020 Innsbruc k Au5tria ## SY NOPSlS T h e interaction of mono-and divalent metal ions with the nucleic acid base pairs A:T and G:C has been studied using a b initio self-consistent field Hartree-Fock computations with minimal basis sets. Energy-optimi:ed structures of the