On the assessment of bioequivalence in a two-period cross-over design
โ Scribed by Herman P. Wijnand
- Book ID
- 113291357
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 526 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0169-2607
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The two-period cross-over design with two sequences of drug administration is a standard experimental design when bioequivalence of one test formulation is to be assessed in comparison with a reference formulation. Previously, an approach based on Fieller's confidence interval has been presented for
In the analysis of a two-period cro88over study GBIZZLE (1965) suggeata that, if a preliminary k t for a period by treatment inbraction (residual effeot, carryover effect) fsignificant at the 10 o/o level, the direct effects of the treatments should be compared by performix$ a t -h t on the data fro