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On the Affinity Regulation of the Metal-Ion-Dependent Adhesion Sites in Integrins

✍ Scribed by Sebastian, Eider San; Mercero, Jose M.; Stote, Roland H.; Dejaegere, Annick; Cossío, Fernando P.; Lopez, Xabier

Book ID
120346367
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
385 KB
Volume
128
Category
Article
ISSN
0002-7863

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## Abstract Three divalent cation binding sites in the integrin β I domain have been shown to regulate ligand binding and adhesion. However, the degree of ligand binding and adhesion varies among integrins. The αLβ2 and α4β7 integrins show an increase in ligand binding affinity and adhesion when on