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Assessing Metal Ion Preference for the Metal Ion-Dependent Adhesion Site (MIDAS) of Platelet Integrin αIIbβ3

✍ Scribed by Negri, Ana; Borrero, Ernesto E.; Provasi, Davide; Coller, Barry S.; Filizola, Marta

Book ID
122290553
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
83 KB
Volume
104
Category
Article
ISSN
0006-3495

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## Abstract Three divalent cation binding sites in the integrin β I domain have been shown to regulate ligand binding and adhesion. However, the degree of ligand binding and adhesion varies among integrins. The αLβ2 and α4β7 integrins show an increase in ligand binding affinity and adhesion when on