On Steroids. Part 417. Effects of 3α-Amino-5α-pregnan-20-one on GABAA Receptor: Synthesis, Activity and Cytotoxicity.
✍ Scribed by Libor Matyas; Alexander Kasal; Zoila Babot Riera; Cristina E. Sunol
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 19 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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Synthesis and in vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor. -A series of 3β-substituted 3α-hydroxy-5α-(24 examples) and -5β-pregnan-20-ones (7 examples) is evaluated as potent allosteric modulators for the γ-aminobutyric acidA (GABAA) re
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