On-line water removal during enzymatic asymmetric esterification in organic media

✍ Scribed by L. Gubicza; A. Szakács-Schmidt

• Book ID: 104647038
• Publisher: Springer-Verlag
• Year: 1995
• Tongue: English
• Weight: 232 KB
• Volume: 9
• Category: Article
• ISSN: 0951-208X
• DOI: 10.1007/bf00156357

✦ Synopsis

Enantioselective esterification

of 2-bromopropionic acid with n-butanol using Candida cylindracea lipase was carried out in n-pentane at various initial water contents.

Reaction rate as well as enantioselectivity decreased at high water content. A heteroazeotropic distillation method was applicable to remove the excess water continuously and to work at the optimum reaction conditions.