On-line post-capillary affinity detection of immunoglobulin G subclasses and monoclonal antibody variants for capillary electrophoresis

The Use of On-line Capillary Electrophor

The Use of On-line Capillary Electrophoresis/Electrospray Ionization with Detection via an Ion Trap Storage/Reflectron Time-of-flight Mass Spectrometer for Rapid Mutation-site Analysis of Hemoglobin Variants

✍ Michael X. Li; Jing-Tao Wu; Lin Liu; David M. Lubman 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB 👁 3 views

Capillary electrophoresis/electrospray ionization using an ion trap storage/reflectron time-of-flight mass spectrometer detector (CE/ESI-IT/reTOF) is used to provide a rapid and sensitive method for analyzing structural variants in the hemoglobin (Hb) β-chain. The Hb α-and β-chains are separated and