On-Line Microdialysis Sample Cleanup for Electrospray Ionization Mass Spectrometry of Nucleic Acid Samples
β Scribed by Liu, Chuanliang; Wu, Qinyuan; Harms, Amy C.; Smith, Richard D.
- Book ID
- 127285289
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 316 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0003-2700
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SigniΓcant advances in the area of microdialysis which allowed more e β ective handling of small volumes (microliters) of samples, more efficient desalting and enhanced mass spectrometric detection sensitivity are described. The previously reported on-line coupling of microdialysis with electrospray
A novel method has been developed for the rapid desalting of proteins and peptides for electrospray ionization mass spectrometry (ESI-MS). Protein and peptide solutions having high salt concentrations were infused into a microdialysis tube which was directly interfaced with a micro-ESI source. The m