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On-Line Coupling of Separation Techniques to NMR

✍ Scribed by Albert, Klaus ;Dachtler, Markus ;Glaser, Tobias ;Händel, Heidi ;Lacker, Tanja ;Schlotterbeck, Götz ;Strohschein, Sabine ;Tseng, Li-Hong ;Braumann, Ulrich

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
184 KB
Volume
22
Category
Article
ISSN
0935-6304

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✦ Synopsis

The hyphenation of chromatographic separation techniques with NMR spectroscopy is one of the most powerful and time-saving methods for the separation and structural elucidation of unknown compounds and molecular compositions of mixtures. Most of the routinely used NMR flow-cells have detection volumes between 40 -180 lL for conventional separations with analytical columns, and the newest designs employ detection volumes in the order of 200 nL for capillary separations. The low flow rates used in capillary chromatography permit the use of deuterated solvents. Unequivocal structural assignment of unknown chromatographic peaks is possible by twodimensional stopped-flow capillary HPLC-NMR experiments.

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