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Olmesartan decreases IL-1β and TNF-α levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis

✍ Scribed by Aurigena Antunes Araújo…

Book ID
120749128
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
725 KB
Volume
386
Category
Article
ISSN
0028-1298

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Effect of telmisartan on levels of IL-1,
Effect of telmisartan on levels of IL-1, TNF-α, down-regulated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model
✍ Araújo, Aurigena A.; Souza, Tatiana O.; Moura, Lígia M.; Brito, Gerly A. C.; Ara 📂 Article 📅 2013 🏛 John Wiley and Sons 🌐 English ⚖ 635 KB

## Aim The aim of this study was to evaluate the effect of telmisartan (TELM) on inflammation, oxidation and the expression of matrix metalloproteinases (MMPs) and the expression RANKL/RANK/OPG in the periodontal tissue of a rat model for ligature-induced periodontitis. ## Materials and methods M