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NF-κBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1β-induced and TNF-α-induced chondrocytes

✍ Scribed by C. Lianxu; J. Hongti; Y. Changlong

Book ID: 113732381
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 552 KB
Volume: 14
Category: Article
ISSN: 1063-4584
DOI: 10.1016/j.joca.2005.10.009

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## Abstract The expression of matrix metalloproteinase‐9 (MMP‐9) has been implicated in progression of atherosclerotic lesions. The role and importance of the signaling pathway in the transcriptional regulation of MMP‐9 in human aortic smooth muscle cells (HASMC) was examined. Tumor necrosis factor